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KMID : 0360220210620121581
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 12 p.1581 ~ p.1591
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Efficacy of Intense Pulsed Light Treatment in Patients with Sjogren’s Syndrome Associated with Meibomian Gland Dysfunction
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Moon Ja-Young
Yoon Hyeon-Jeong
Yoon Kyung-Chul
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Abstract
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Purpose: To investigate the efficacy of intense pulsed light (IPL) treatment in patients with meibomian gland dysfunction (MGD) associated with Sjogren’s syndrome.
Methods: This study included 43 patients with MGD and Sjogren’s syndrome. Patients received either IPL with meibomian gland expression (IPL/MGX) (n = 22) or MGX only (n = 21). Treatments were administered three times at a 3-week interval. Patients were followed up 6 weeks after the end of the treatment. Ocular Surface Disease Index (OSDI), tear film breakup time with fluorescein dye (FBUT), non-invasive tear breakup time, tear meniscus height (TMH), Schirmer test, SICCA ocular surface staining score, meibum quality score (MQS), and meibum expression score (MES) were evaluated at each visit. Meibomian gland dropouts (meiboscore) and tear film lipid layer grade were measured using keratography.
Results: OSDI, FBUT, corneal surface staining score, MQS, meiboscore, and tear film lipid layer grade improved after IPL/MGX treatment (p < 0.05). In both treatment groups, MES significantly improved (p < 0.01 and p < 0.05 for IPL/MGX and MGX groups, respectively). The Schirmer test score, conjunctival surface staining score, and TMH after treatment were not significantly different between the groups. After treatment, the IPL/MGX group had significantly lower OSDI, FBUT, corneal staining score, MQS, and MES, but higher FBUT, compared with the MGX group (p < 0.05).
Conclusions: IPL treatment effectively improved tear film, ocular surface parameters, meibomian gland function, and lipid layer grade in patients with Sjogren’s syndrome and MGD.
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KEYWORD
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Intense pulsed light, Meibomian gland dysfunction, Sjogren’s syndrome
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